ANTI-AGING, YOUTH ENHANCING and LIFE SUSTAINING
What do Alzheimer’s disease, colon cancer, arthritis, heart disease and wrinkles have in common?”
This famous question doctor N.V. Perricone, the renowned anti ageing expert often asks his students.
The answer is inflammation that causes gradual progressive cellular damage. Inflammation is the basis of disease and one of its triggers is a rapid rise in blood sugar levels.
The conversion of food into energy and heat in our bodies is accomplished in tiny ‘spark plugs’ within each of our cells called mitochondria. When we are young we have up to 2000 of these spark plugs in every cell but as we age this is reduced to only 1000, a drop of 50%.
Elevated blood sugar causes a number of chemical reactions in the body that induces inflammation. When the skin cells undergo oxidative stress it produces the proinflammatory cytokines, the ‘serial killers’ that activate many chemicals, one of them being an enzyme called collagenases, forming the glycation reaction that digests the collagen. This powerful and silent process causes skin aging resulting in micro scars that lead to wrinkles.
The deterioration of mitochondria is an important cause of aging. A significant cause of this deterioration is the accumulation of destructive free radicals causing oxidative stress that disables enzymes and other chemicals.
Using Alpha Lipoic Acid and -Acetyl Carnitine increases mitochondrial ATP activity while protecting the cell from oxidative stress.
Physiologically the body contains small amounts of alpha lipoic acid inside the mitochondria that remain locked inside the enzyme system and do not flow freely in the cell. Alpha lipoic acid when taken as a nutritional supplement performs as an antioxidant as well as a booster of energy production in our cells by helping the mitochondria converts food into energy.
Years of research reveals that about 95% of cellular energy occurs in the mitochondria and diseases of aging are increasingly being referred to as "mitochondria disorders."
Acetyl-L-carnitine is the biologically active amino acid involved in the transport of fatty acids into the cell's mitochondria for the purpose of producing energy. It can increase muscle mass and convert body fat into energy.
Acetyl-L-carnitine has been shown to protect brain cells against aging-related degeneration and to improve mood, memory and cognition. People use acetyl-L-carnitine to maintain their immune competence and reduce the formation of the aging pigment lipofuscin.
The most important effect of acetyl-L-carnitine, however, is to maintain the function of the cell's energy powerhouse, the mitochondria.
During the past few years more and more studies have showed that:
- Acetyl-carnitine enhances the correct rhythmic release of growth hormone as well as preventing hormonal depletion from stress
- ALC is helpful in treatment of fibromyalgia during menopause
- ALC overcomes leptin resistance in the brain
- ALC with melatonin offset the effects of stress on sleep patterns
- ALC is the key supplement for overcoming a wide variety of cellular resistances
Alpha Lipoic Acid - The Universal, Metabolic Antioxidant
Alpha lipoic acid (ALA) has been called the “universal” antioxidant because it is both fat and water soluble. It works in both the fatty cell plasma membrane and the aqueous interior of the cell. By penetrating into and out of the cell alpha lipoic acid brings antioxidant protection wherever it is needed.
Research reveals that ALA boosts glutathione levels in cells, has potent antioxidant action in almost all the tissues of the body, and is a co-factor for some of the key enzymes involved in generating energy from food and oxygen in mitochondria. It increases cellular activity and vitality.
One of the most beneficial effects of alpha lipoic is its ability to regenerate and protect other essential antioxidants such as vitamins C and E, coenzyme Q10, and glutathione - the antioxidants inside the cells.
The other benefits of alpha lipoic acid supplementation:
- Protects DNA ( the cell’s genetic code)
- Inhibits the activation of transcription factor NF-kB, thus reducing cellular inflammation
- Controls AP-1, that helps remodel the collagen
- Inhibits glycosylation (the abnormal attachment of sugar to protein) which causes cross-linking of collagen making it inflexible and stiff
- Acts as a strong anti-inflammatory agent
- Decreases insulin resistance
- Enhances insulin function
- Helps regulate blood sugar levels
- Acts synergistically with all antioxidant systems
1. Practitioner Information from Daniel Weber Seminar2005
2. N.V. Perricone,MD The Perricone Prescription HarperCollins 2002